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Breast Implant Diseases
Some women with breast implants have reported health
problems that they believe are related to their implants,
but most studies of these diseases have failed to show an
association with breast implants. There also have been
concerns about possible, but unproven, effects on health.
Most of the health concerns about breast implants are
related to the body reacting to a foreign material, such as
silicone gel. These diseases are discussed below.
Connective Tissue Diseases (CTDs) and Related Disorders
These are a group of diseases and disorders related to
the immune system and to the connective tissue of the body
(e.g., muscle, tendon, bone, etc.) that supports body
structures and binds body parts together. The body's immune
system is the network of cells that protect against
infectious diseases. Antibodies are one type of substance
the body produces to fight off infectious agents.
The cause of CTDs is unknown. Some CTDs have autoimmune
characteristics in that a woman's immune system attacks her
own cells as if they were foreign.
CTDs with autoimmune characteristics include:
• lupus
• rheumatoid arthritis
• polymyositis
• dermatomyositis
• progressive systemic sclerosis or scleroderma.
CTDs without autoimmune characteristics include:
• fibromyalgia
• chronic fatigue syndrome.
Some women with breast implants have experienced the
diseases or disorders listed above, as well as a variety of
signs and symptoms that could be related to the immune
system or to the connective tissues of the body. However,
these signs and symptoms are not considered a defined
disease or disorder. These signs and symptoms include:
• pain and swelling of joints
• tightness
• redness or swelling of the skin
• swollen glands or lymph nodes
• unusual or unexplained fatigue
• swelling of the hands and feet
• excessive hair loss
• memory problems
• headaches
• muscle weakness or burning.
Signs and symptoms, such as those bulleted above, may be
present in women without CTD or related disorders or in
women without breast implants. Individual cases alone cannot
scientifically prove or disprove a connection between CTDs
and related disorders and breast implants.
Some doctors and women have thought that these signs and
symptoms are part of a new disease which is related to
silicone and have called the disease "human adjuvant
disease," "silicone related syndrome," "atypical disease,"
or other names. The IOM report37 stated "The diagnosis of
this condition could depend on the presence of a number of
symptoms that are nonspecific and common in the general
population. Thus, there does not appear to be even
suggestive evidence of a novel [new] syndrome in women with
breast implants." So, it is unclear at this time whether or
not the signs and symptoms experienced by these women are
related to their implants. In some cases, women have
reported fewer symptoms after the implants were removed. In
other cases, there was no change in signs and symptoms after
the implants were removed.
Studies have shown that some women with silicone gell
filled breast implants produced antibodies to their own
collagen (a connective tissue protein), but we do not know
how often these antibodies occur in the general population,
and there are no data that show these antibodies cause CTDs
and related disorders. 38,39,40There are reports of women
with implants who have a variety of autoantibodies. (Autoantibodies
are antibodies that your body makes that accidentally target
your own tissues.) However, the presence of these
autoantibodies does not mean that a woman has an increased
risk of actually developing a CTD or related disorder.
When considered together, these studies indicate that the
risk of developing a typical or defined CTD or related
disorder due to having a breast implant is low. However,
these studies have not been large enough to resolve the
question of whether or not breast implants slightly increase
the risk of CTDs or related disorders. Researchers must
study a large group of women without breast implants who are
of similar age, health, and social status and who are
followed for a long time (such as 10-20 years) before a
relationship between breast implants and these diseases can
conclusively be made.
There have been reports of women with fibromyalgia following
breast implants, and a preliminary study conducted by FDA41
found an association between self-reported fibromyalgia and
extracapsular rupture diagnosed by MRI. However, this
association has not been repeated in a similar study based
on a large group of Danish women42 and the weight of the
epidemiological evidence published in the literature does
not support an association between fibromyalgia and breast
implants.
Cancers
The IOM report43 indicates that breast cancer is no more
common in women with breast implants than those without
breast implants. While not conclusive, cancer rates have
been reported to be slightly higher for some types of
cancers. Cancers rates that have been higher in more than
one study are lung and vulva. Because these cancers may be
related to other factors that were not examined in these
studies (such as smoking) these studies are not conclusive.
More information on cancer and breast implants is
available at the National
Cancer Institute website
Neurological Symptoms/Diseases
Some women with breast implants have reported that they
have neurological symptoms (such as difficulties with
vision, sensation, muscle strength, walking, balance,
thinking or remembering things) or diseases (such as
multiple sclerosis) related to their implants. Several
studies have indicated that women with implants are not at
an increased risk of being hospitalized with neurological
disease compared to other women. The IOM report44 found no
basis for thinking that women with implants were more likely
to have neurological diseases or symptoms.
Since the IOM report, Winther, et al.45 published
additional follow-up of the Danish group of 1,653 women with
cosmetic breast implant surgery at private clinics in
Denmark compared to a comparison group of 1,736 women who
underwent other types of cosmetic procedures. No increased
risks for neurological disorders were found in the breast
implant patients. However, it should be noted that these
studies are limited in that rare disorders cannot be
addressed.
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